成功获得小鼠iNSCs,并证实其与野生型神经干细胞具备相似的表型和分化能力;
重编程小鼠成纤维细胞获得iNSCs
成功证明了表达胶质细胞来源神经营养因子GDNF的自体骨髓间充质干细胞(BMMSCs)对非人灵长类PD模型具有保护作用。
成功完成了自体iPSCs获得的多巴胺能神经元移植治疗非人灵长类PD模型的工作,并证明其安全有效。
世界上首次从理论上证明了iNSCs对PD模型动物具有治疗作用。
成功利用iPSCs技术建立了研究家系遗传神经退行性疾病的细胞模型。世界首次将病人和健康人的iPSCs细胞系分化为成熟的小脑浦肯野神经元,为后续研究II型小脑共济失调的细胞学机制建立了细胞模型。
成功将成人外周血单个核细胞诱导为人诱导神经干细胞(hiNSCs)。取材更简单、安全,患者接受度更高
人类外周血单个核细胞定向分化为iNSC-DAP,移植PD小鼠模型获得有效性数据
iNSC-DAP治疗PD灵长类研究获得有效数据,启动国内首个IIT临床研究
7月18日,全球首例使用iNSC-DAP自体细胞移植治疗帕金森病的神经外科手术在首都医科大学宣武医院成功完成
宣武医院首例自体诱导神经干细胞来源的多巴胺能神经前体细胞治疗帕金森病患者随访一年取得安全性和有效性
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